Catalog Home Page

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

Miura, T., Brumme, C. J., Brockman, M. A., Brumme, Z. L., Pereyra, F., Block, B. L., Trocha, A., John, M., Mallal, S., Harrigan, P. R. and Walker, B. D. (2009) HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers. Journal of Virology, 83 (7). pp. 3407-3412.

[img]
Preview
PDF - Published Version
Download (128kB)
Link to Published Version: http://dx.doi.org/10.1128/JVI.02459-08
*Subscription may be required

Abstract

Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8<sup>+</sup> T lymphocytes are believed to play a crucial role in viral containment, but the degree of immune imprinting and compensatory mutations in EC is unclear. We obtained plasma gag, pol, and nef sequences from HLA-diverse subjects and found that 30 to 40% of the predefined HLA-associated polymorphic sites show evidence of immune selection pressure in EC., compared to approximately 50% of the sites in chronic progressors. These data indicate ongoing viral replication and escape from cytotoxic T lymphocytes are present even in strictly controlled HTV-1 infection.

Publication Type: Journal Article
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Publisher: American Society for Microbiology
Copyright: © 2009, American Society for Microbiology
URI: http://researchrepository.murdoch.edu.au/id/eprint/2838
Item Control Page Item Control Page

Downloads

Downloads per month over past year