P09-15. Selection of higher avidity HLA-restricted T cell responses as a viral adaptation strategy
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Keane, N.M., Roberts, S.G., Laird, R., Chopra, A., Krishnan, T., Almeida, C.M., Bronke, C., Mallal, S., James, I. and John, M. (2009) P09-15. Selection of higher avidity HLA-restricted T cell responses as a viral adaptation strategy. Retrovirology, 6 (Suppl 3, 22 October 2009). P128.
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Link to Published Version: http://dx.doi.org/10.1186/1742-4690-6-S3-P128
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Abstract
Loss of immune reactivity due to HIV mutational escape is well described. Data generated from a large population-based study (n>800) suggested that certain CD8 T cell epitopes are created as a result of HIV adaptation and are associated with enhanced viral replication. Here we sought to investigate the HLA-restricted T-cell responses associated with seven such adaptations.
| Publication Type: | Journal Article |
|---|---|
| Murdoch Affiliation: | Centre for Clinical Immunology and Biomedical Statistics |
| Publisher: | BioMed Central |
| Copyright: | © 2009 Keane et al |
| URI: | http://researchrepository.murdoch.edu.au/id/eprint/2823 |
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