Relationships between fibre intake and the expression of genes linked to incretin secretion in the gastrointestinal tract of weaner pigs
Pluske, J.R., Hernández, A., Mansfield, J., Auckland, C.H. and Kim, J.C. (2013) Relationships between fibre intake and the expression of genes linked to incretin secretion in the gastrointestinal tract of weaner pigs. In: Manipulating Pig Production XIV. Proceedings of the 14th Australasian Pig Science Association (APSA) Biennial Conference, 24 - 27 November, Melbourne, Australia p. 116.
Dietary fibre [predominately non-starch polysaccharides (NSP) and resistant starch] is fermented to short chain fatty acids (SCFA) by the microbiota in the distal ga,strointestinal tract (GIT). The activation of G-protein coupled receptors (GPRs), such as GPR41 and GPR43, by SCFA in the epithelium activates the proglucagon (PG) gene in the L cells of the GITto secrete incretins such as glucagon-like peptides (GLP-1, GLP-2) and peptide YY (PYY), that in turn are implicated in the control of GIT structure and function (Black et al., 2009). We are unaware of any work conducted in weaner pigs in this area. The hypothesis tested was that the expression of genes coding for GPRs and PG is influenced by the intake of NSP.
|Publication Type:||Conference Paper|
|Murdoch Affiliation:||School of Veterinary and Life Sciences|
|Publisher:||Australasian Pig Science Association|
|Copyright:||© Australasian Pig Science Association 2013|
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