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Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers

Pasternak, K., Pasternak, A., Gupta, P., Veedu, R.N. and Wengel, J. (2011) Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers. Bioorganic & Medicinal Chemistry, 19 (24). pp. 7407-7415.

Link to Published Version: http://dx.doi.org/10.1016/j.bmc.2011.10.052
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Abstract

Efficient synthesis of a novel anthracene-functionalized 2′-amino-LNA phosphoramidite derivative is described together with its incorporation into oligodeoxynucleotides. Two DNA strands with the novel 2′-N-anthracenylmethyl-2′-amino-LNA monomers can be effectively cross-linked by photoligation at 366 nm in various types of DNA constructs. Successful application of three differently functionalized 2′-amino-LNA monomers in self-assembled higher ordered structures for simultaneous cross-linking and monitoring of assembly formation is furthermore demonstrated.

Publication Type: Journal Article
Publisher: Elsevier Ltd.
Copyright: © 2011 Elsevier Ltd.
URI: http://researchrepository.murdoch.edu.au/id/eprint/27430
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