Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers
Pasternak, K., Pasternak, A., Gupta, P., Veedu, R.N. and Wengel, J. (2011) Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers. Bioorganic & Medicinal Chemistry, 19 (24). pp. 7407-7415.
*Subscription may be required
Efficient synthesis of a novel anthracene-functionalized 2′-amino-LNA phosphoramidite derivative is described together with its incorporation into oligodeoxynucleotides. Two DNA strands with the novel 2′-N-anthracenylmethyl-2′-amino-LNA monomers can be effectively cross-linked by photoligation at 366 nm in various types of DNA constructs. Successful application of three differently functionalized 2′-amino-LNA monomers in self-assembled higher ordered structures for simultaneous cross-linking and monitoring of assembly formation is furthermore demonstrated.
|Publication Type:||Journal Article|
|Copyright:||© 2011 Elsevier Ltd.|
|Item Control Page|