Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences
Kim, K.T., Veedu, R.N., Seo, Y.J. and Kim, B.H. (2014) Quencher-free molecular beacons as probes for oligonucleotides containing CAG repeat sequences. Chemical Communications, 50 (13). p. 1561.
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We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of their PyU units.
|Publication Type:||Journal Article|
|Publisher:||Royal Society of Chemistry|
|Copyright:||© 2014 Royal Society of Chemistry|
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