Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease
van der Walt, J.M., Martin, E.R., Scott, W.K., Zhang, F., Nance, M.A., Watts, R.L., Hubble, J.P., Haines, J.L., Koller, W.C., Lyons, K., Pahwa, R., Stern, M.B., Colcher, A., Hiner, B.C., Jankovic, J., Ondo, W.G., Allen, F.H., Goetz, C.G., Small, G.W., Mastaglia, F., Roses, A.D., Stajich, J.M., Booze, M.W., Fujiwara, K., Gibson, R.A., Middleton, L.T., Scott, B.L., Pericak-Vance, M.A. and Vance, J.M. (2003) Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease. Neurology, 60 (7). pp. 1189-1191.
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Recently, the authors demonstrated linkage in idiopathic PD to a region on chromosome 8p that contains the N-acetyltransferase genes, NAT1 and NAT2. The authors examined NAT1 and NAT2 for association with PD using family-based association methods and single nucleotide polymorphisms (SNPs). The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals).
|Publication Type:||Journal Article|
|Publisher:||Lippincott Williams & Wilkins|
|Copyright:||© 2003 American Academy of Neurology|
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