Catalog Home Page

Giardia duodenalis: Exposure to metronidazole inhibits competitive interactions between isolates of the parasite in vitro

Thompson, R.C.A., Lymbery, A.J., Pearce, D.A., Finn, K.C., Reynoldson, J.A. and Meloni, B.P. (1996) Giardia duodenalis: Exposure to metronidazole inhibits competitive interactions between isolates of the parasite in vitro. Journal of Parasitology, 82 (4). pp. 679-683.

[img]
Preview
PDF - Published Version
Download (960kB) | Preview

    Abstract

    The competitive interactions of genetically distinct isolates of Giardia duodenalis with different growth rates were studied in vitro. Electrophoretic analysis of mixed cultures showed that competition between 2 cloned isolates occurs under normal in vitro culture conditions, with faster-growing isolates outcompeting those with slower growth rates. The addition of sublethal concentrations of metronidazole to clonal mixtures in vitro prevented the competitive exclusion, which was seen in normal culture. This apparently occurred because the drug reduced the growth rate of the faster-growing but not the slower-growing clone.

    Publication Type: Journal Article
    Murdoch Affiliation: School of Veterinary Studies
    Publisher: American Society of Parasitologists
    URI: http://researchrepository.murdoch.edu.au/id/eprint/2421
    Item Control Page

    Downloads

    Downloads per month over past year