Identification and recombinant expression of a 30 kDa outer envelope lipoprotein of Brachyspira hyodysenteriae
La, T., Lee, B.J., Mikosza, A.S.J. and Hampson, D.J. (2000) Identification and recombinant expression of a 30 kDa outer envelope lipoprotein of Brachyspira hyodysenteriae. In: 16th International Pig Veterinary Society Congress, 17 - 20 September, Melbourne, Australia p. 35.
Swine dysentery (SD) is a contagious mucohaemorrhagic diarrhoeal disease of pigs, characterised by extensive inflammation and necrosis of the epithelial surface of the large intestine (1). Economic losses due to SD result mainly from growth retardation, costs of medication, and mortality (2). To date, no completely sensitive and specific assays are available for the detection of antibodies against the aetiological agent, Brachyspira hyodysenteriae. Recently, we identified and cloned a 30 kDa outer membrane lipoprotein (BmpB) which is specific to B. hyodysenteriae and is recognised by experimentally and naturally infected pigs. We propose the use of recombinant BmpB as an antigen for future development of an improved serological test for SD diagnosis.
|Publication Type:||Conference Paper|
|Murdoch Affiliation:||School of Veterinary and Biomedical Sciences|
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