A review of major histocompatibility complex-disease associations in man and dog
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The organization and biology of the Major Histocompatibility Complexes (MHC) of man (HLA) and dog (DLA) are reviewed, and a summary is presented of laboratory techniques used to define allotypes. The nomenclature of this field and the mechanisms of disease association with the MHC are discussed. Currently recognized HLA-disease associations are enumerated, with emphasis on the value of the complement C4 marker. DLA-disease association studies into autoimmune disease, allergy and neoplasia are reviewed.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary Studies|
|Copyright:||© 1987 Geo Abstracts Ltd.|
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