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Investigating heterogeneity of growth and drug response in mesotheliomas

Otadoy, Roxanne (2013) Investigating heterogeneity of growth and drug response in mesotheliomas. Honours thesis, Murdoch University.

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The prognosis for patients with malignant mesothelioma is very poor with patient response to therapy highly variable. This project was aimed at investigating the degree of heterogeneity in the responses to treatment amongst mesothelioma cell lines which have all arisen due to asbestos exposure. Despite the use of the same carcinogen, a number of variabilities amongst these cancers are still present. Avenues of investigation initially tried to determine if the variability in response was due to heterogeneity in the proliferation of malignant mesothelioma cells. Different growth rates were observed for cell lines grown in culture and in vivo. Cells showed different degrees of response to treatment with different chemotherapeutic agents. An attempt was made to determine the mode of cell death undergone by cells in their response to the treatments. Further investigation is warranted into the validity of these results because if the differences found in the phenotype of the cells were accurate, it could direct individualised therapeutic strategies to target the uniqueness of malignant mesothelioma.

Publication Type: Thesis (Honours)
Murdoch Affiliation: School of Veterinary and Life Sciences
Supervisor: Robinson, Cleo and Greene, Wayne
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