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Convenient Asymmetric Synthesis of (1R,3R)-(+)- and (1S,3S)-(-)-1,3-Diphenylpropane-1,3-diols

Roos, G. and Donovan, A.R. (1996) Convenient Asymmetric Synthesis of (1R,3R)-(+)- and (1S,3S)-(-)-1,3-Diphenylpropane-1,3-diols. Synlett, 1996 (12). pp. 1189-1190.

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Kinetic resolution via a Sharpless epoxidation serves as the key step to provide the useful C2 chiral auxiliaries (R,R)- and (S,S)-1,3-diphenylpropane-1,3-diols, in good yield and high enantiomeric purity from the commercially available 1,3-diphenylprop-1-en-3-one.

Sharpless epoxidation - Kinetic resolution - Asymmetric synthesis - C2 symmetric 1,3-diols - 1,3-Diphenylpropan-1,3-diols

Publication Type: Journal Article
Murdoch Affiliation: School of Chemical and Mathematical Science
Publisher: Thieme
Copyright: © 1996 Georg Thieme Verlag
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