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Body composition in mice maintained with cyclic periods of food restriction and refeeding

Bell, R.R. and McGill, T.J. (1987) Body composition in mice maintained with cyclic periods of food restriction and refeeding. Nutrition Research, 7 (2). pp. 173-182.

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The effect of cyclic periods of underfeeding and overfeeding on body composition and energy efficiency was investigated in adult female CD1 Swiss mice. Four groups of mice were studied for 8 weeks: 1) Controls, fed stock diet ad libitum, 2) Overfed, fed stock diet plus a varied selection of highly palatable human foods (cafeteria feeding), 3) Cyclic-fed, given restricted amounts of stock diet (80% of controls) and cafeteria diet on alternate weeks, and 4) Restricted, fed 80% of the food consumed by the controls. The restricted mice had lower body weight, carcass energy content and energy expenditure than the other groups. The overfed mice had increased energy intake, energy expenditure, food efficiency, carcass fat and energy stores. The cyclic-fed mice had higher food intake than the controls but lower intake than the overfed mice. The cyclic-fed mice had increased food efficiency, increased carcass fat and carcass energy compared to the controls but values were less than for the overfed mice. Carcass energy was 224±8 kJ, controls; 314±18 kJ, overfed; 277±14 kJ, cyclic-fed and 173±9 kJ, restricted mice. Carcass energy was highly correlated with total energy consumed (r=0.592, p<0.001). Both regular and periodic consumption of an energy dense diet did increase energy intake, energy efficiency and carcass energy stores. However, there was no evidence that repeated periods of food restriction and refeeding increased body fat stores.

Publication Type: Journal Article
Publisher: Elsevier Inc.
Copyright: © 1987 Published by Elsevier Inc.
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