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Canine nasal aspergillosis: Results of treatment using clotrimazole as a topical agent

Burbidge, H.M., Clark, W.T., Read, R.A., Labuc, R., Davey, T. and Broome, C. (1997) Canine nasal aspergillosis: Results of treatment using clotrimazole as a topical agent. Australian Veterinary Practitioner, 27 (2). pp. 79-83.


This case series describes the response of canine nasal aspergillosis to topical clotrimazole treatment in 11 dogs. The antifungal agent was administered to affected dogs by one of three methods: A) twice daily administration for 10 days via surgically implanted, indwelling catheters into the frontal sinuses and nasal cavity (three dogs); B) a single treatment consisting of one-hour contact-time with the drug immediately following catheter placement (three dogs); and C) non-invasive intranasal single infusion via the nostrils with a one-hour contact time (five dogs). All dogs were assessed for recurrence of the disease (follow-up time range two to 24 months). In one of the three dogs and two of the three dogs treated by method A and B respectively, clinical signs of aspergillosis recurred. However, four of the five dogs treated by method C were free of disease at the fourth week post-treatment assessment. The remaining dog required one further intranasal infusion before complete resolution occurred. From this small case series, it appears that non-invasive intranasal infusion of topical clotrimazole appears to be an effective treatment for canine nasal Aspergillus infections. This simple non-surgical treatment can be easily performed by veterinarians in general practice.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: Australian Small Animal Veterinary Association
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