The first complete papillomavirus genome characterized from a marsupial host: a novel isolate from Bettongia penicillata
Bennett, M.D., Reiss, A., Stevens, H., Heylen, E., Van Ranst, M., Wayne, A., Slaven, M., Mills, J.N., Warren, K.S., O'Hara, A.J. and Nicholls, P.K. (2010) The first complete papillomavirus genome characterized from a marsupial host: a novel isolate from Bettongia penicillata. Journal of Virology, 84 (10). pp. 5448-5453.
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The first fully sequenced papillomavirus (PV) of marsupials, tentatively named Bettongia penicillata papillomavirus type 1 (BpPV1), was detected in papillomas from a woylie (Bettongia penicillata ogilbyi). The circular, double-stranded DNA genome contains 7,737 bp and encodes 7 open reading frames (ORFs), E6, E7, E1, E2, E4, L2, and L1, in typical PV conformation. BpPV1 is a close-to-root PV with L1 and L2 ORFs most similar to European hedgehog PV and bandicoot papillomatosis carcinomatosis virus types 1 and 2 (BPCV1 and -2). It appears that the BPCVs arose by recombination between an ancient PV and an ancient polyomavirus more than 10 million years ago.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary and Biomedical Sciences|
|Publisher:||American Society for Microbiology|
|Copyright:||2010, American Society for Microbiology|
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