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The occurrence of spontaneous lymphomas but not adenomas or sarcomas in rats treated with sustained release naltrexone

Kelty, E., Nicholls, P.K., O'Neil, G., Harrison, Z., Chan, C-T, Symons, P., Reece, A.S. and Hulse, G. (2012) The occurrence of spontaneous lymphomas but not adenomas or sarcomas in rats treated with sustained release naltrexone. Clinical & Experimental Pharmacology, 02 (01).

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Abstract

Naltrexone has been observed to have both a stimulatory and inhibitory effect on the development of tumours in rodents, potentially mediated by changes to the neuroendocrine system as a result of blockade of the opiate receptors, with the period of blockade and the tumour type thought to be influential. This study examined the occurrence of spontaneous tumours in rats treated with a sustained release naltrexone preparation. Materials and methods: 27 male and 27 female rats were randomized into three equal treatment groups (A, B and C). Rats in group A were implanted with a single naltrexone implant tablet, rats in group B were implanted with a single polymer implant tablet (placebo) and rats in group C underwent a sham procedure (control). Three different groups of spontaneous tumours were observed; lymphomas, adenomas and sarcomas. Lymphomas (4 tumours/3 rats) were observed solely in naltrexone treated rats, while adenomas (9 tumours/5 rats) and sarcomas (4 tumours/3 rats) were only observed in the placebo and the control groups. The data suggests that the association of naltrexone on the development of tumours maybe dependent on tumour type. Long term exposure to naltrexone appears to have both a stimulatory and inhibitory effect on tumours in rats, dependent on tumour type.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Publisher: OMICS Publishing Ggroup
Copyright: © 2012 Kelty E, et al.
Notes: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://researchrepository.murdoch.edu.au/id/eprint/17898
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