Iron overload diseases: the chemical speciation of non-heme iron deposits in iron loaded mammalian tissues

St. Pierre, T.G., Chua‐anusorn, W., Webb, J. and Macey, D.J. (2000) Iron overload diseases: the chemical speciation of non-heme iron deposits in iron loaded mammalian tissues. Hyperfine Interactions, 126 (1-4). pp. 75-81.

Abstract

57Fe Mössbauer spectra of iron overloaded human spleen, rat spleen and rat liver tissue samples at 78 K were found to consist of a quadrupole doublet (major component) with magnetic sextet (minor component with fractional spectral area Fs). The distributions of Fs for spleen tissue from two different clinically identifiable groups (n = 7 and n = 12) of thalassemic patients were found to be significantly different. The value of Fs for dietary-iron loaded rat liver was found to rise significantly with age/duration (up to 24 months) of iron loading.