Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability
Ouadi, A., Loussouarn, A., Morandeau, L., Remaud, P., Faivre-Chauvet, A., Webb, J. and Gestin, J-F (2004) Influence of trans-1,2-diaminocyclohexane structure and mixed carboxylic/phosphonic group combinations on samarium-153 chelation capacity and stability. European Journal of Medicinal Chemistry, 39 (5). pp. 467-472.
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A simple procedure was developed to compare chelating agents for 153Sm complexes as a preliminary step to synthesise bifunctional analogues. Several variables affecting the efficiency of complex stability were investigated, such as the pre-organisation concept, cavity size, and the nature of coordination sites. Four semi-rigid agents incorporating carboxylic and/or phosphonic groupings fixed at trans-1,2-diaminocyclohexane were evaluated for their 153Sm chelation properties, and competition studies were performed. Data on the stability of the best chelating agent compound 3: trans-cyclohexane-1,2-bis(aminomethylphosphonic)-N,N′-bis(ethyl-2- iminodiacetic acid) in human serum are presented.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Chemical and Mathematical Science|
|Publisher:||Elsevier Masson SAS|
|Copyright:||© 2004 Elsevier SAS.|
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