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Incidence of and risk factors for canine osteosarcoma in Western Australia 2007-2009

Lane, Amy (2012) Incidence of and risk factors for canine osteosarcoma in Western Australia 2007-2009. Masters by Research thesis, Murdoch University.

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Abstract

This thesis consists of 4 components:

Part One is a comprehensive log of the first 500 cases seen as an oncology resident at Perth Veterinary Oncology and an assessment of the proportion of different tumour cases presented during this time. Lymphoma was the most common disease seen, comprising 122/500 (24.4%) of cases. There were 88.4% canine cases and 11.6% feline cases. The majority of dogs were crossbreeds; however, the three most common pure breeds seen were the Labrador, golden retriever and Staffordshire bull terrier.

Part Two provides a description of the cases classified as ‘Tumours of the Skeletal System’. Dogs with a confirmed diagnosis of osteosarcoma are then described. The patient signalment and disease presentation are compared and contrasted to previous studies to determine whether osteosarcoma in our cohort of dogs is a similar entity.

Part Three is a description of reported risk factors for the development of osteosarcoma. It includes a literature review demonstrating the evidence supporting or refuting these risks.

Part Four is a retrospective analysis of 33 canine patients diagnosed with appendicular osteosarcoma treated with amputation and an adjuvant chemotherapy protocol consisting of two doses of doxorubicin given two weeks apart, followed by four doses of carboplatin given at three weekly intervals. This chemotherapy protocol has not been previously described. The most effective adjuvant chemotherapy protocol for the treatment of canine appendicular osteosarcoma post limb amputation has not yet been determined, and this study of a novel protocol may help to further define this.

Publication Type: Thesis (Masters by Research)
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Supervisor: Wyatt, Kenneth
URI: http://researchrepository.murdoch.edu.au/id/eprint/16534
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