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Longitudinal study of serum thyroid hormone levels during normal pregnancy

O'Leary, P.C., Boyne, P., Atkinson, G., Mileham, K.-J. and James, I. (1992) Longitudinal study of serum thyroid hormone levels during normal pregnancy. International Journal of Gynecology & Obstetrics, 38 (3). pp. 171-179.

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We undertook a prospective longitudinal study of thyroid function in 60 normal pregnant women and measured serum concentrations of T 4, triiodothyronine (T 3), T-uptake, thyroxine binding globulin (TBG), free thyroxine index (FTI), free T 4, albumin and thyrotropin (TSH). From these data we established reference ranges for each of these analytes for each trimester and examined the interrelationships between laboratory measurements of thyroid function tests. We observed significant increases in serum concentrations of thyrotropin and decreases in free T 4, assays commonly used as first line investigations of thyroid activity during pregnancy. However, the 95th centile intervals for both analytes remained within the reference range for nonpregnant women.

Publication Type: Journal Article
Murdoch Affiliation: School of Mathematical and Physical Sciences
Publisher: Elsevier Ireland Ltd
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