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IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis

Xu, W., li, R., Dai, Y., Wu, A., Wang, H., Cheng, C., Qiu, W., Lu, Z., Zhong, X., Shu, Y., Kermode, A.G. and Hu, X. (2013) IL-22 secreting CD4+ T cells in the patients with neuromyelitis optica and multiple sclerosis. Journal of Neuroimmunology, 261 (1-2). pp. 87-91.

Link to Published Version: http://dx.doi.org/10.1016/j.jneuroim.2013.04.021
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Abstract

Interleukin (IL)-22 secreting CD4+ T (Th22) cells and IL-22 are involved in the pathogenesis of autoimmune disease, but their role in neuromyelitis optica (NMO) and multiple sclerosis (MS) is unclear. We measured the proportion of Th22, Th17, CD4+IL-22+IL-17A+ T cells and serum IL-22 in NMO and MS patients. The proportion of Th22 cells, Th17 cells and serum IL-22 were increased in patients with NMO and MS. Our findings suggest that increased Th22 cells may play an important role in the pathogenesis of NMO and MS.

Publication Type: Journal Article
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Publisher: Elsevier
Copyright: 2013 Elsevier B.V.
URI: http://researchrepository.murdoch.edu.au/id/eprint/15756
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