Intraperitoneal medetomidine: a novel analgesic strategy for postoperative pain management in pregnant sheep
Murdoch, F.R., Maker, G.L., Nitsos, I., Polglase, G.R. and Musk, G.C. (2013) Intraperitoneal medetomidine: a novel analgesic strategy for postoperative pain management in pregnant sheep. Laboratory Animals, 47 (1). pp. 66-70.
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The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed. Eleven sheep were studied: six were treated with a medetomidine loaded osmotic pump delivering 10 mu L/h (3 mu g/kg/h medetomidine); and five with a saline loaded osmotic pump (control). Serial blood samples were taken and analysed to determine plasma medetomidine levels. Medetomidine was absorbed from the peritoneal cavity and a steady plasma concentration was achieved within 10 h, mean (SD) peak concentration was 2.87 (0.22) ng/mL. Sheep receiving medetomidine analgesia had significantly lower pain scores at 10 h than controls. Four control sheep required rescue analgesia, compared with 0 in the treatment group. Delivery of 3 mu g/kg/h medetomidine by an intraperitoneal osmotic pump to pregnant sheep in the 24 h postoperative period provides adequate plasma concentrations of medetomidine for analgesia without sedation.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary and Life Sciences|
|Publisher:||Royal Society of Medicine Press|
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