Complejos metálicos como potenciales antimaláricos con blanco de acción: hemozoína (Metal complexes as potential antimalarials with hemozoin as target of action)
Castro, W. and Navarro, M. (2012) Complejos metálicos como potenciales antimaláricos con blanco de acción: hemozoína (Metal complexes as potential antimalarials with hemozoin as target of action). Avances en Quimica, 7 (2). pp. 135-144.
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Malaria is a serious problem of health worldwide, synthesis of drugs more effective to combat this disease is a high-priority task for the control of the disease; one of the most promising strategies is the modification of compounds with known or potential activity through the incorporation of a transition metal into its molecular structure, in order to avoid the resistance of parasites and increase biological activity. In this paper we present the latest studies on the synthesis of metal-chloroquine, in the process of developing new chemotherapeutic agents more effective against malaria and less toxic to the host, still the hemozoin the principal target of action.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Chemical and Mathematical Science|
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