Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function
Fernandez, S., Price, P., McKinnon, E.J., Nolan, R.C. and French, M.A. (2006) Low CD4+ T-cell counts in HIV patients receiving effective antiretroviral therapy are associated with CD4+ T-cell activation and senescence but not with lower effector memory T-cell function. Clinical Immunology, 120 (2). pp. 163-170.
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The adverse effects of immune activation on CD4+ T-cell recovery and the relationship between CD4+ T-cell counts and effector T-cell function were examined in HIV-1 patients receiving long-term effective ART. Patients with nadir CD4+ T-cell counts <100/;Cl, > 12 months on ART and >6 months with <50 HIV RNA copies/ml were stratified by current CD4+ T-cell counts and patients from the lowest (n = 15) and highest (n = 12) tertiles were studied. We assessed proliferation (Ki67), activation (HLA-DR, CD38) and replicative senescence (CD57) by flow cytometry and CD4+ T-cell responses to CMV by IFN-;3 ELISpot. Proportions of CD4+ T-cells expressing HLA-DR or CD57 were strong univariate predictors of total (P = 0.0002 and P = 0.002) and naive (P < 0.0001 and P < 0.0001, respectively) CD4+ T-cell counts, suggesting that CD4+ T-cell activation drives the depletion of naive CD4+ T-cells. This was clearest in patients with a small/undetectable thymus. IFN-;3 responses to CMV were similar in patients with low or high CD4+ T-cell counts.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Centre for Clinical Immunology and Biomedical Statistics|
|Publisher:||Academic Press Inc.|
|Copyright:||2006 Elsevier Inc.|
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