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Pathophysiology of Mesocestoides corti infection in the mouse

White, T.R., Thompson, R.C.A., Penhale, W.J., Pass, D.A. and Mills, J.N. (1982) Pathophysiology of Mesocestoides corti infection in the mouse. Journal of Helminthology, 56 (02). pp. 145-154.

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Liver histology and serum enzyme and protein changes were studied in two strains of mice showing different initial susceptibilities to infection with Mesocestoides corti. The results show an increase in ALT and AST levels during the period of invasion and proliferation in the liver and a decrease in the levels of these two enzymes following encapsulation of the parasite in the liver and liver regeneration. A progressive loss of albumin was accompanied by increases in the levels of the beta- and gamma-globulins. These changes are discussed in the light of our knowledge of the effects of this parasite upon its host.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary Studies
Publisher: Cambridge University Press
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