The effects of selective immunosuppression on resistance toMesocestoides corti in strains of mice showing high and low initial susceptibility

White, T.R., Thompson, R.C.A. and Penhale, W.J. (1982) The effects of selective immunosuppression on resistance toMesocestoides corti in strains of mice showing high and low initial susceptibility. Zeitschrift fur Parasitenkunde, 69 (1). pp. 91-104.

Abstract

Previous work has shown that C57BL/6 mice had the lowest initial susceptibility to Mesocestoides corti of six strains of mice examined. Parasite burdens in this strain and in CBA/H mice, a strain showing a higher initial susceptibility to M. corti, were compared following selective immunosuppressive treatments. Irradiation, splenectomy and the administration of cyclophosphamide and methyl prednisolone all resulted in higher parasite burdens in C57BL/6 mice. In contrast these treatments had a minimal effect on parasite burdens in CBA/H mice. In the light of these results the role of antibody in controlling parasite proliferation is discussed.