HLA-associated viral polymorphism in chronically HIV-1-infected Japanese cohort: analysis of four-digit HLA allele level
Chikata, T., Carlson, J.M., Tamura, Y., Brumme, Z.L., Naruto, T., Hashimoto, M., Borghan, M.A., John, M., Mallal, S., Gatanaga, H., Oka, S. and Yakiguchi, M. (2012) HLA-associated viral polymorphism in chronically HIV-1-infected Japanese cohort: analysis of four-digit HLA allele level. Retrovirology, 9 (Suppl 2).
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It is assumed that the difference of HLA class I distribution among ethnic populations influences HIV evolution because HLA-restricted immune pressure selects escape mutations. Approximately 50% of HLA class I alleles are shared between Japanese and Caucasians. The analysis of HLA-associated polymorphism (HLA-AP) in both Japanese and Caucasian infected with clade B virus is expected to clarify the difference of HIV-1 evolution between both populations.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Institute for Immunology and Infectious Diseases|
|Copyright:||© 2012 Chikata et al|
|Notes:||Poster Presentation at AIDS Vaccine 2012, Boston, 9-12 September, 2012.|
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