Limited evidence for alterations in Gag-mediated HIV replication capacity over the course of the North American epidemic (1979-present)
Cotton, L., Chopera, D., Penney, K., Carlson, J., Martin, E., Le, A., Kuang, T., Walker, B., Fuchs, J., Buchbinder, S., Wagner, T., John, M., Mallal, S., Koblin, B., Mayer, K., Poon, A., Brockman, M. and Brumme, Z. (2012) Limited evidence for alterations in Gag-mediated HIV replication capacity over the course of the North American epidemic (1979-present). Retrovirology, 9 (Suppl 2). P157.
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The extent to which HIV replication capacity (RC) has changed over the epidemic’s course, and the influence of HLA-associated immune pressure as its driving force remains unknown. We performed a comparative study of immune escape and RC in historic (1979-1989) and modern Gag subtype B sequences from North America.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Institute for Immunology and Infectious Diseases|
|Copyright:||© 2012 Cotton et al|
|Notes:||Poster Presentation at AIDS Vaccine 2012, Boston, 9-12 September, 2012.|
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