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The effect of lentinan on the resistance of mice to Mesocestoides corti

White, T.R., Thompson, R.C.A., Penhale, W.J. and Chihara, G. (1988) The effect of lentinan on the resistance of mice to Mesocestoides corti. Parasitology Research, 74 (6). pp. 563-568.

Link to Published Version: http://dx.doi.org/10.1007/BF00531635
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Abstract

CBA/H mice were given the immunomodulator lentinan in multipe, ascending doses before (prophylactic) or after (therapeutic) inoculation with tetrathyridia of Mesocestoides corti or as a single prophylactic dose. The latter was without effect, but increasing multiple prophylactic and therapeutic doses of lentinan resulted in a marked reduction in the numbers of parasites in the peritoneal cavity, particularly in those mice that received lentinan therapeutically. In mice that received multiple doses of lentinan, liver granulomas were larger than in controls and there was more collagen deposition and fibrosis. Encapsulated parasites were dead or dying, and such damage appeared to be mediated by increased numbers of macrophages and giant cells.

Publication Type: Journal Article
Murdoch Affiliation: School of Veterinary Studies
Publisher: Springer Verlag
Copyright: © Springer-Verlag 1988
URI: http://researchrepository.murdoch.edu.au/id/eprint/10765
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