In vitro and in vivo efficacy of epsiprantel against Echinococcus granulosus
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In vitro, epsiprantel at a concentration of 10 μg ml−1 caused tegumental damage and death of protoscoleces, juveniles (seven-day-old) and adult (37-day-old) Echinococcus granulosus. Degenerative changes and death occurred more rapidly in the older parasites. Similarly, epsiprantel was more effective against adult (28-day-old) than seven-day-old experimental infections of E granulosus in dogs. Oral doses of 2·5, 5 and 7·5 mg kg−1 were greater than 96 per cent, 99·9 per cent and 99·99 per cent active, respectively, against mature worms, whereas in seven-day-old infections doses of 5, 7·5 and 10 mg kg−1 produced greater than 94 per cent, 90 per cent and 99·8 per cent reduction in worm burdens, respectively. No side effects from treatment were seen.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary Studies|
|Publisher:||W. B. Saunders Co., Ltd.|
|Copyright:||© 1991 Published by Elsevier Ltd.|
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