The efficacy of two electron transport inhibitors (720C80 and 993C76) on murine strongyloidiasis: A comparison with albendazole
Armson, A., Thompson, R.C.A., Reynoldson, J.A., Grubb, W.B. and Mendis, A.H.W. (1993) The efficacy of two electron transport inhibitors (720C80 and 993C76) on murine strongyloidiasis: A comparison with albendazole. International Journal for Parasitology, 23 (6). pp. 815-817.
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The clinical efficacy of albendazole (ABZ) in the treatment of chronic uncomplicated strongyloidiasis has been reported to be highly variable. In our murine model of strongyloidiasis a single oral dose of 5 and 10 mg kg-1 ABZ reduced (at day 4 post infection) the faecal larval count (FLC) by 54.2 ± 12.5% and 81.5 ± 10.2%, respectively. 100 mg kg-1 ABZ reduced the FLC by 100%. Two inhibitors of protozoan and filarial electron transport (720C80 and 993C76) inhibited the endogenous O2 consumption of intact infective (L3) larvae of S. ratti by > 50% at 2 x 10-5 M in vitro, and reduced the FLC by 72 ± 9.3% and 62.0 ± 10.3% respectively in vivo, at a dose of 70 mg kg-1. These results suggest that compounds designed as selective inhibitors of protozoan electron transport have significant efficacy against murine strongyloidiasis and may prove useful in the management of human strongyloidiasis.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||School of Veterinary Studies|
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