Vitamin B12 as a carrier for the oral delivery of insulin
Petrus, A.K., Vortherms, A.R., Fairchild, T.J. and Doyle, R.P. (2007) Vitamin B12 as a carrier for the oral delivery of insulin. ChemMedChem, 2 (12). pp. 1717-1721.
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The noninvasive delivery of insulin continues to be a major goal for the treatment of diabetes mellitus. Oral-enteric administration would make insulin delivery easier and more effective, as higher patient compliance and improved glycemic control are likely; yet the oral-enteric pathway has been unfeasible owing to insulin's susceptibility to proteolytic degradation and inefficient enteric uptake. Herein we show that a noninvasive oral delivery route for insulin is possible through the vitamin B12 uptake pathway. In diabetic rat models, insulin-B12 conjugates can significantly lower blood glucose levels when administered orally.
|Publication Type:||Journal Article|
|Publisher:||John Wiley and Sons Ltd|
|Copyright:||© 2007 Wiley-VCH Verlag GmbH & Co. KGaA.|
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