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Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro

Morgan, U.M., Reynoldson, J.A. and Thompson, R.C.A. (1993) Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro. Antimicrobial agents and chemotherapy, 37 (2). pp. 328-331.

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    Abstract

    Previous studies in our laboratory have shown that albendazole is effective against Giardia spp. in vitro and in vivo, prompting an investigation of the effects of several related benzimidazoles (BZs) on the viability of this protozoan parasite. A range of BZs was tested, and their effects were compared with those of a number of microtubule inhibitors. The effects produced by the two types of drugs were markedly similar, namely, trophozoite detachment and distortion of morphology and general structure, indicating a potential antimicrotubule mode of action for BZs. Mebendazole, albendazole, and fenbendazole proved to be among the most effective BZs tested, exhibiting apparent irreversibility. Nocodazole, oxfendazole, and albendazole sulfoxide, among others, produced transient inhibitions only. Further studies are required to evaluate all available BZs and other antigiardial agents to ensure the development of the most effective and safest antigiardial agent possible.

    Publication Type: Journal Article
    Murdoch Affiliation: School of Veterinary Studies
    Publisher: American Society for Microbiology
    Copyright: © 1993 American Society for Microbiology
    Publishers Website: http://aac.asm.org/content/37/2/328.full.pdf+html
    URI: http://researchrepository.murdoch.edu.au/id/eprint/10120
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