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Multilocus genotypic analysis of Cryptosporidium parvum isolates from different hosts and geographical origins.

Spano, F., Putignani, L., Crisanti, A., Sallicandro, P., Morgan, U.M., Le Blancq, S.M., Tchack, L., Tzipori, S. and Widmer, G. (1998) Multilocus genotypic analysis of Cryptosporidium parvum isolates from different hosts and geographical origins. Journal of Clinical Microbiology, 36 (11). pp. 3255-3259.

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    Abstract

    The genetic analysis of oocysts recovered from the stools of humans and animals infected with Cryptosporidium parvum has consistently shown the existence of two distinct genotypes. One of the genotypes is found exclusively in some human infections, whereas the other genotype is found in human as well as in animal infections. On the basis of these observations and the results of published epidemiological studies with single polymorphic markers, the existence of two separate transmission cycles has been postulated, one exclusively anthroponotic and the other involving both animals and humans. To test this hypothesis, C. parvum isolates of different geographic and host origins were analyzed by using unlinked genetic polymorphisms. A total of 28 isolates originating from Europe, North and South America, and Australia were examined. Isolates clustered into two groups, one comprising both human and animal isolates and the other comprising isolates only of human origin. The absence of recombinant genotypes is consistent with two reproductively isolated populations within the species C. parvum.

    Publication Type: Journal Article
    Murdoch Affiliation: School of Veterinary and Biomedical Sciences
    Publisher: American Society for Microbiology
    Copyright: © 1998 American Society for Microbiology
    Publishers Website: http://jcm.asm.org/content/36/11/3255.full.pdf+htm...
    URI: http://researchrepository.murdoch.edu.au/id/eprint/10091
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