Variation in Cryptosporidium: towards a taxonomic revision of the genus (Review)
Morgan, U.M., Xiao, L., Fayer, R., Lal, A.A. and Thompson, R.C.A. (1999) Variation in Cryptosporidium: towards a taxonomic revision of the genus (Review). International Journal for Parasitology, 29 (11). pp. 1733-1751.
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Cryptosporidium is an important cause of enteric disease in humans and other animals. Limitations associated with conventional diagnostic methods for cryptosporidiosis based on morphological features, coupled with the difficulty of characterising parasites isolated in the laboratory, have restricted our ability to clearly identify species. The application of sensitive molecular approaches has obviated the necessity for laboratory amplification. Such studies have found considerable evidence of genetic heterogeneity among isolates of Cryptosporidium from different species of vertebrate, and there is now mounting evidence suggesting that a series of host-adapted genotypes/strains/species of the parasite exist. In this article, studies on the molecular characterisation of Cryptosporidium during the last 5years are reviewed and put into perspective with the past and present taxonomy of the genus. The predictive value of achieving a sound taxonomy for the genus Cryptosporidium with respect to understanding its epidemiology and transmission and controlling outbreaks of the disease is also discussed.
|Publication Type:||Journal Article|
|Murdoch Affiliation:||Western Australian State Agricultural Biotechnology Centre|
|Copyright:||© 1999 Australian Society for Parasitology Inc.|
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